Increasingly, adult Indigenous language learners are being identified as the “missing generation” of who hold great potential to contribute revival languages by acting middle ground between Elders, children and youth within their communities. Our research project NEȾOLṈEW̱ ‘one mind, one people’ investigated learning through popular Mentor-Apprentice Program (MAP) method (Leanne Hinton, 2001). Over course 14 months, our team conducted 133 interviews with four groups participants involved in MAP. The were current past apprentices, mentors, administrators MAP programs British Columbia, Canada. primary interest was learn about successes challenges for learning, but we also included interview questions that gave space share how participating may have affected them. During thematic analysis (Braun & Clarke, 2006, 2014) noticed repeating comments across all participant on involvement impacted own community’s wellbeing. Six exploratory themes identified: • Language loss negatively impacts wellbeing people: “[the word] doesn’t just mean a bad, misbehaving child, it means poor child has been uprooted […] is disconnected from culture” relationship burden among MAP: “there’s so much be done. that’s exhausting part it. It’s trying teach at same time” Strengthening apprentices become future community leaders: “it brings huge sense pride helps me an inspiration anyone else” Elder’s healing becoming mentors: “we once again believe ourselves where can feel free” Cultural spiritual health healing: “I am keeping something very precious alive speaking my language” Health outcomes: that... pushed sobriety, me... I was”. Although studies reported protective effects use (Ball Moselle, 2013; Hallett, Chandler, Lalonde, 2007; McIvor, 2013), health-related outcomes revitalization efforts, including MAP, remain underexplored (Whalen, Moss, Baldwin, 2016). In addition discussing six study, paper proposes these inform area References Ball, J., K. (2013). Contributions culture aboriginal head start urban northern communities children’s A review theory research. Prepared Division Children, Seniors Healthy Development, Promotion Chronic Disease Prevention Branch. Braun, V., V. (2006). Using psychology. Qualitative Research Psychology, 3, 77–101. http://doi.org/10.1191/1478088706qp063oa (2014). What “thematic analysis” offer researchers? International Journal Studies Well-Being, 9, 26152. http://doi.org/10.3402/qhw.v9.26152 D., M. C. E. (2007). Aboriginal knowledge suicide. Cognitive 22(3), 392–399. http://doi.org/10.1016/j.cogdev.2007.02.001 L. (2001). master-apprentice program. Hinton Hale (Eds.), green book practice (pp. 217–226). San Diego, CA: Academic Press. O. Protective well-being people Proceedings 17th FEL Conference, XVII: Endangered Languages Beyond Boundaries: Community Connections, Collaborative Approaches Cross-Disciplinary 123–131). Foundation association University Carleton. Whalen, D. H., M., (2016). Healing language: Positive physical indigenous use. F1000Research, 5(852). http://doi.org/10.12688/f1000research.8656.1

Every day thousands of surgical procedures are performed to replace or repair tissue that has been damaged through disease trauma. The developing field engineering (TE) aims regenerate tissues by combining cells from the body with highly porous scaffold biomaterials, which act as templates for regeneration, guide growth new tissue. This article describes functional requirements, and types, materials used in state art scaffolds applications. Furthermore, it challenges where future research direction is required this rapidly advancing field.

DNA Sensing Is a (c)GAS is normally localized to the nucleus, and so its cytoplasmic localization sends off alarm bells immune system because it indicates that virus may have entered. But how does actually detect (see Perspective by O'Neill )? Sun et al. (p. 786 , published online 20 December) identify cyclic GMP-AMP (cGAMP) cyclase (cGAS), which can bind directly catalyze production of cGAMP. cGAMP then acts as second messenger activate downstream signaling events trigger antiviral immunity. Wu 826 show cGAMP, produced in response DNA, binds activates adaptor protein STING.

Generalized linear models with nonlinear feature transformations are widely used for large-scale regression and classification problems sparse inputs. Memorization of interactions through a wide set cross-product effective interpretable, while generalization requires more engineering effort. With less engineering, deep neural networks can generalize better to unseen combinations low-dimensional dense embeddings learned the features. However, over-generalize recommend relevant items when user-item high-rank. In this paper, we present Wide & Deep learning---jointly trained networks---to combine benefits memorization recommender systems. We productionized evaluated system on Google Play, commercial mobile app store over one billion active users million apps. Online experiment results show that significantly increased acquisitions compared wide-only deep-only models. have also open-sourced our implementation in TensorFlow.

We report the draft genome of black cottonwood tree, Populus trichocarpa . Integration shotgun sequence assembly with genetic mapping enabled chromosome-scale reconstruction genome. More than 45,000 putative protein-coding genes were identified. Analysis assembled revealed a whole-genome duplication event; about 8000 pairs duplicated from that event survived in A second, older is indistinguishably coincident divergence and Arabidopsis lineages. Nucleotide substitution, tandem gene duplication, gross chromosomal rearrangement appear to proceed substantially more slowly Arabidopsis. has , ranging on average 1.4 1.6 homologs for each gene. However, relative frequency protein domains two genomes similar. Overrepresented exceptions include associated lignocellulosic wall biosynthesis, meristem development, disease resistance, metabolite transport.

A single entity, the AMP‐activated protein kinase (AMPK), phosphorylates and regulates in vivo hydroxymethylglutraryl‐CoA reductase acetyl‐CoA carboxylase (key regulatory enzymes of sterol synthesis fatty acid synthesis, respectively), probably many additional targets. The is activated by high AMP low ATP via a complex mechanism, which involves allosteric regulation, promotion phosphorylation an upstream (AMPK kinase), inhibition dephosphorylation. This protein‐kinase cascade represents sensitive system, cellular stresses that deplete ATP, thus acts like fuel gauge. Our central hypothesis that, when it detects ‘low‐fuel’ situation, protects cell switching off ATP‐consuming pathways (e.g. synthesis) on alternative for generation oxidation). Native heterotrimer consisting catalytic α subunit, β γ subunits, are also essential activity. All three subunits have homologues budding yeast, components SNF1 complex. glucose starvation (which yeast leads to depletion) genetic studies shown involved derepression glucose‐repressed genes. raises intriguing possibility AMPK may regulate gene expression mammals. AMPK/SNF1 found higher plants, this appears be ancient system evolved protect cells against effects nutritional or environmental stress.